Studies at prestigious research institutions around the world are showing compelling results for psychedelics as treatments for serious mental health and substance use disorders when administered in clinical settings paired with therapeutic oversight. These psychedelic-assisted therapies are rapidly moving towards mainstream clinical applications. With unprecedented interest at hand, it is imperative to understand the clinical evidence that demonstrates the efficacy, effectiveness, and safety of this class of interventions. Psychedelic Medicine: A Review of Clinical Research for a Class of Rapidly-Emerging Behavioral Health Interventions is a review of seven psychedelic compounds, including a brief history, tolerability and safety considerations, a summary of clinical evidence by conditions, and recommendations for future adoption and/or research.
Across more than 200 relevant peer-reviewed studies covered in this report, the aggregate evidence is positive. While each compound has different, specific applications, the clinical evidence for PAT is showing noteworthy levels of effectiveness. In fact, compared to treatment as usual, such as psychopharmacology and talk therapy, a growing number of studies of these compounds demonstrate higher levels of short- and long-term effectiveness.